Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression

Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy Breast Pump Accessories (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approache

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Malignant lymphoma in Jordan : A retrospective analysis of 347 cases according to the world health organization classification.

Background: Most studies describing the subtypes of lymphoma in Jordan were carried out in the 1980s at a time when immunohistochemi-cal facilities were unavailable.Using a database established after immu-nohistochemical studies were introduced, we determined the frequency of the various types of nodal and extranodal lymphomas in the adult and paed

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